# STOCKHOLM 1.0
#=GF ID fn3
#=GF AC PF00041.13
#=GF DE Fibronectin type III domain
#=GF AU Sonnhammer ELL
#=GF GA 8.0 7.2
#=GF NC 7.9 7.9
#=GF TC 8.0 7.2
#=GF SE Swissprot_feature_table
#=GF TP Domain
#=GF BM hmmbuild -FHMM_ls.ann SEED.ann
#=GF BM hmmcalibrate --seed 0 HMM_ls
#=GF BM hmmbuild -f -FHMM_fs.ann SEED.ann
#=GF BM hmmcalibrate --seed 0 HMM_fs
#=GF AM byscore
#=GF RN [1]
#=GF RM 2169613
#=GF RT Structural design and molecular evolution of a cytokine receptor
#=GF RT superfamily. 
#=GF RA Bazan JF; 
#=GF RL PNAS USA 1990;87:6934-6938.
#=GF RN [2]
#=GF RM 7528812
#=GF RT Tracing the spread of fibronectin type III domains in bacterial
#=GF RT glycohydrolases. 
#=GF RA Little E, Bork P, Doolittle R; 
#=GF RL J Mol Evol 1994;39:631-643.
#=GF RC Definition of fibronectin domains 
#=GF RN [3]
#=GF RM 2992939
#=GF RT Primary structure of human fibronectin: differential splicing
#=GF RT may generate at least 10 polypeptides from a single gene. 
#=GF RA Kornblihtt AR, Umezawa K, Vibe-Pedersen K, Baralle FE; 
#=GF RL EMBO J 1985;4:1755-1759.
#=GF DR INTERPRO; IPR003961;
#=GF DR HOMSTRAD; fn3;
#=GF DR SMART; FN3;
#=GF DR SCOP; 1ttf; sf;
#=GF DR PRINTS; PR00014;
#=GF DR PROSITE; PDOC00214;
#=GF SQ 106

#=GS TIE1_HUMAN/644-729    AC P35590.1
#=GS NCAM1_BOVIN/509-597   AC P31836.1
#=GS LAR_DROME/417-503     AC P16621.2
#=GS NGCA_CHICK/700-794    AC Q03696.2
#=GS MPSF_CHICK/499-585    AC Q02173.1
#=GS MPSF_CHICK/371-457    AC Q02173.1
#=GS MPSF_CHICK/600-684    AC Q02173.1
#=GS NRCAM_CHICK/623-709   AC P35331.1
#=GS MYPC2_CHICK/631-717   AC P16419.3
#=GS MYLK_CHICK/1318-1403  AC P11799.2
#=GS CNTN2_CHICK/602-692   AC P28685.1
#=GS MPSF_CHICK/699-785    AC Q02173.1
#=GS MPSF_CHICK/801-887    AC Q02173.1
#=GS MYPC2_CHICK/924-1006  AC P16419.3
#=GS LAR_DROME/322-404     AC P16621.2
#=GS FAS2_SCHAM/530-616    AC P22648.2
#=GS PTP69_DROME/332-425   AC P16620.2
#=GS TENA_CHICK/1227-1306  AC P10039.2
#=GS TENA_CHICK/1136-1215  AC P10039.2
#=GS TENA_HUMAN/1529-1608  AC P24821.2
#=GS TENA_CHICK/1045-1124  AC P10039.2
#=GS TENA_HUMAN/1255-1335  AC P24821.2
#=GS PTPRB_HUMAN/22-103    AC P23467.1
#=GS TIE2_HUMAN/639-724    AC Q02763.1
#=GS LAR_DROME/515-598     AC P16621.2
#=GS FINC_BOVIN/577-660    AC P07589.3
#=GS TIE1_HUMAN/446-533    AC P35590.1
#=GS PTPRK_MOUSE/290-376   AC P35822.1
#=GS TIE2_HUMAN/444-529    AC Q02763.1
#=GS TIE2_HUMAN/543-626    AC Q02763.1
#=GS 7LESS_DROVI/1917-1997 AC P20806.1
#=GS PTPRZ_HUMAN/312-401   AC P23471.3
#=GS FAS2_SCHAM/642-735    AC P22648.2
#=GS NCAM1_BOVIN/610-691   AC P31836.1
#=GS ITB4_HUMAN/1127-1208  AC P16144.4
#=GS UFO_HUMAN/327-411     AC P30530.2
#=GS KALM_CHICK/543-641    AC P33005.2
#=GS PTP10_DROME/958-1044  AC P35992.3
#=GS PTP69_DROME/236-321   AC P16620.2
#=GS NRG_DROME/917-1007    AC P20241.2
#=GS FINC_BOVIN/689-768    AC P07589.3
#=GS FINC_BOVIN/780-858    AC P07589.3
#=GS IL7RA_HUMAN/129-221   AC P16871.1
#=GS PTP10_DROME/405-485   AC P35992.3
#=GS FINC_BOVIN/1417-1499  AC P07589.3
#=GS FINC_RAT/1266-1346    AC P04937.2
#=GS FINC_BOVIN/1327-1406  AC P07589.3
#=GS TENA_CHICK/1317-1395  AC P10039.2
#=GS FINC_BOVIN/875-955    AC P07589.3
#=GS FINC_BOVIN/1511-1590  AC P07589.3
#=GS TENA_CHICK/864-945    AC P10039.2
#=GS TENA_CHICK/593-671    AC P10039.2
#=GS FINC_BOVIN/1142-1225  AC P07589.3
#=GS FINC_BOVIN/1693-1771  AC P07589.3
#=GS FINC_BOVIN/1236-1316  AC P07589.3
#=GS FINC_BOVIN/1601-1680  AC P07589.3
#=GS TENA_CHICK/1494-1571  AC P10039.2
#=GS TENA_CHICK/956-1033   AC P10039.2
#=GS TENA_CHICK/682-767    AC P10039.2
#=GS TENA_CHICK/774-853    AC P10039.2
#=GS TENA_CHICK/1406-1483  AC P10039.2
#=GS FINC_BOVIN/1782-1861  AC P07589.3
#=GS PTPRB_HUMAN/1085-1162 AC P23467.1
#=GS PTPRB_HUMAN/1173-1250 AC P23467.1
#=GS PTPRB_HUMAN/554-632   AC P23467.1
#=GS PTPRB_HUMAN/643-725   AC P23467.1
#=GS PTPRB_HUMAN/731-808   AC P23467.1
#=GS PTPRB_HUMAN/995-1074  AC P23467.1
#=GS PTPRB_HUMAN/467-543   AC P23467.1
#=GS PTPRB_HUMAN/907-984   AC P23467.1
#=GS PTPRB_HUMAN/112-192   AC P23467.1
#=GS PTPRB_HUMAN/1355-1434 AC P23467.1
#=GS PTP10_DROME/583-661   AC P35992.3
#=GS PTP10_DROME/312-394   AC P35992.3
#=GS PTP10_DROME/217-301   AC P35992.3
#=GS PTP10_DROME/123-205   AC P35992.3
#=GS EPHA2_HUMAN/329-420   AC P29317.1
#=GS EPHA1_HUMAN/333-431   AC P21709.3
#=GS EPHB2_CHICK/326-422   AC P28693.3
#=GS EPHA3_CHICK/325-421   AC P29318.1
#=GS PTP10_DROME/864-944   AC P35992.3
#=GS PTPRB_HUMAN/1261-1344 AC P23467.1
#=GS TIE1_HUMAN/545-632    AC P35590.1
#=GS 7LESS_DROME/1799-1891 AC P13368.2
#=GS PHB_ALCFA/344-418     AC P12625.1
#=GS APU_THETY/928-1009    AC P16950.1
#=GS CHIT_STRLI/142-219    AC P36909.1
#=GS CHIA1_BACCI/465-542   AC P20533.1
#=GS GUNB_CELFI/651-733    AC P26225.1
#=GS CHIX_STROI/169-240    AC Q05638.1
#=GS APU_THETY/1165-1248   AC P16950.1
#=GS KALM_CHICK/177-269    AC P33005.2
#=GS CNTN1_CHICK/799-884   AC P14781.1
#=GS CNTN2_CHICK/807-896   AC P28685.1
#=GS NRG_DROME/815-905     AC P20241.2
#=GS L1CAM_HUMAN/812-907   AC P32004.2
#=GS LAR_DROME/709-800     AC P16621.2
#=GS PTP99_DROME/171-259   AC P35832.2
#=GS EPHA2_HUMAN/436-519   AC P29317.1
#=GS LAR_DROME/909-995     AC P16621.2
#=GS NRCAM_CHICK/928-1014  AC P35331.1
#=GS EPHB2_CHICK/437-521   AC P28693.3
#=GS EPHA4_MOUSE/441-525   AC Q03137.1
#=GS ITB4_HUMAN/1220-1310  AC P16144.4
#=GS ITB4_HUMAN/1641-1728  AC P16144.4
#=GS ITB4_HUMAN/1528-1612  AC P16144.4

#=GS TENA_CHICK/1227-1306  DR PDB; 1qr4 B; 18-77;
#=GS TENA_CHICK/1227-1306  DR PDB; 1qr4 A; 18-77;
#=GS ITB4_HUMAN/1127-1208  DR PDB; 1qg3 B; 1127-1208;
#=GS ITB4_HUMAN/1127-1208  DR PDB; 1qg3 A; 1127-1208;
#=GS TENA_CHICK/1317-1395  DR PDB; 1qr4 B; 88-166;
#=GS TENA_CHICK/1317-1395  DR PDB; 1qr4 A; 88-166;
#=GS ITB4_HUMAN/1220-1310  DR PDB; 1qg3 B; 1220-1310;
#=GS ITB4_HUMAN/1220-1310  DR PDB; 1qg3 A; 1220-1310;

TIE1_HUMAN/644-729            P.PAP.RHLHAQAL...SDSEIQLTWKHPE..ALPGPISKYVVEV...QV
NCAM1_BOVIN/509-597           P.SSP.SIDQVEP....YSSTAQVQFDEPEA.TGGVPILKYKAEWR...A
LAR_DROME/417-503             E.SAP.RNVQVRTL...SSSTMVITWEPPE..TPNGQVTGYKV.Y...YT
NGCA_CHICK/700-794            PERNP.GGVHGEGN...ETGNLVITWEPLPPQAWNAPWARYRVQWR...P
MPSF_CHICK/499-585            P.GPP.TNVHASEI...SKTYVVLSWDPPV..PRGREPLTYFIEK...SM
MPSF_CHICK/371-457            P.GAP.MDVKCHDA...NRDYVIVTWKPPNT.TSQNPVIGYFVDK...CE
MPSF_CHICK/600-684            P.SAP.GRVVATRN...TKTSVVVQWDKPK...HEENLYGYYIDY...SV
NRCAM_CHICK/623-709           P.NPP.LDLELTGQ...LERSIELSWVPGE..ENNSPITNFVIEY...ED
MYPC2_CHICK/631-717           P.DPP.QSVRVTSV...GEDWAVLSWEAPPF.DGGMPITGYLMER...KK
MYLK_CHICK/1318-1403          P.DPPAGTPCASDI...RSSSLTLSWYGSSY.DGGSAVQSYTVEI...WN
CNTN2_CHICK/602-692           PPGPP.GGVVVRDI...GDTTVQLSWSRGF..DNHSPIARYSIEAR...T
MPSF_CHICK/699-785            P.SYP.HGITLLNC...DGHSMTLGWKAPKY.SGGSPILGYYIDKR...E
MPSF_CHICK/801-887            P.GPA.YDLTVCEV...RNTSLVLLWKAPVY.EGKSPITGYLVDY...KE
MYPC2_CHICK/924-1006          P.GPP.QAVRVMEV...WGSNALLQWEPPKD.DGNAEISGYTVQK...AD
LAR_DROME/322-404             P.TAP.TDVQISEV...TATSVRLEWSYK....GPEDLQYYVIQY...KP
FAS2_SCHAM/530-616            P.SAV.LQVKMDVM...TATTVTFKFFGPGN.DGGLPTKNYAVQY...KQ
PTP69_DROME/332-425           Y.DPI.FIPKVETTG.STASTITIGWNPPPP.DLIDYIQYYELIV...SE
TENA_CHICK/1227-1306          E.PEV.DNLLVSDA...TPDGFRLSWTAD.....DGVFDSFVLKIR..DT
#=GR TENA_CHICK/1227-1306  SS X.XXX.XXXXXXXX...XXXXXXEEEE--.....SS--SEEEEEEE..-T
TENA_CHICK/1136-1215          H.PEV.GELTVSDI...TPESFNLSWTTT.....NGDFDAFTIEI...ID
TENA_HUMAN/1529-1608          L.PLL.ENLTISDI...NPYGFTVSWMAS.....ENAFDSFLVTV...VD
TENA_CHICK/1045-1124          E.PEL.GNLSVSET...GWDGFQLTWTAA.....DGAYENFVIQV...QQ
TENA_HUMAN/1255-1335          E.VPDMGNLTVTEV...SWDALRLNWTTP.....DGTYDQFTIQV...QE
PTPRB_HUMAN/22-103            AEPER.CNFTLAESK.ASSHSVSIQWRIL......GSPCNFSLIY...SS
TIE2_HUMAN/639-724            P.PQP.ENIKISNI...THSSAVISWTILD....GYSISSITIRY...KV
LAR_DROME/515-598             P.SQP.SNFRATDI...GETAVTLQWTKPT..HSSENIVHYELYW...ND
FINC_BOVIN/577-660            T.SGP.VQVIITETP.SQPNSHPIQWSAPE....SSHISKYILRW...KP
TIE1_HUMAN/446-533            P.PVPLAAPRLLTK...QSRQLVVSPLVSF..SGDGPISTVRLHYR..PQ
PTPRK_MOUSE/290-376           P.PRPIAPPQLLGV...GPTYLLIQLNANSI.IGDGPIILKEVEYR...M
TIE2_HUMAN/444-529            L.PKPLNAPNVIDT...GHNFAVINISSEPY.FGDGPIKSKKLLY...KP
TIE2_HUMAN/543-626            L.PPP.RGLNLLPK...SQTTLNLTWQPIF..PSSEDDFYVEVERR...S
7LESS_DROVI/1917-1997         S.YAPLPPLQLIEL...NAYGMTLAWPGT.....PDALSSLTLEC...QS
PTPRZ_HUMAN/312-401           S.SEP.ENVQADPE...NYTSLLVTWERPRV.VYDTMIEKFAVLY...QQ
FAS2_SCHAM/642-735            T.SGT.ENEVVVSP...YPNRYELRWQVPA..DNGEPITHYSVKS...CP
NCAM1_BOVIN/610-691           P.SAP.KLEGQMGE...DGNSIKVKLIKQD..DGGSPIRHYLVKYR...A
ITB4_HUMAN/1127-1208          L.GAP.QNPNAKAA...GSRKIHFNWLPP.....SGKPMGYRVKY...WI
#=GR ITB4_HUMAN/1127-1208  SS -.---.EEEEEEE-...STT-EEEEEE--.....SS---EEEEEE...EE
UFO_HUMAN/327-411             L.GPP.ENISATR....NGSQAFVHWQEPRA.PLQGTLLGYRLAY...QG
KALM_CHICK/543-641            L.AKP.ENLSASFIVQEGNITGHFSWKISKA.VLHQPMTGFQVTW...AE
PTP10_DROME/958-1044          P.GRV.ERFHPTDV...QPSEINFEWSLPSS.EANGVIRQFSIAY...TN
PTP69_DROME/236-321           V.PQV.SIDFAKAV...GANKIYLNWTVND...GNDPIQKFFITL...QE
NRG_DROME/917-1007            P.SPV.QGLDAYPL...GSSAFMLHWKKPL..YPNGKLTGYKIYY...EE
FINC_BOVIN/689-768            P.VVA.TSESVTEI...TASSFVVSWVSA.....SDTVSGFRVEY...EL
FINC_BOVIN/780-858            P.DAP.PDPTVDQV...DDTSIVVRWSRP.....RAPITGYRIVY...SP
IL7RA_HUMAN/129-221           P.EAP.FDLSVIYR..EGANDFVVTFNTSHLQKKYVKVLMHDVAYR..QE
PTP10_DROME/405-485           P.LPV.RNLRSIND..DKTNTMIITWEADP....ASTQDEYRIVYH.ELE
FINC_BOVIN/1417-1499          S.DVP.RDLEVIAA...TPTSLLISWDAP.....AVTVRYYRITY...GE
FINC_RAT/1266-1346            V.PQL.TDLSFVDI...TDSSIGLRWTPLN....SSTIIGYRITV...VA
FINC_BOVIN/1327-1406          L.DSP.SGIDFSDI...TANSFTVHWIAP.....RATITGYRIRHH...P
TENA_CHICK/1317-1395          V.GSP.KGISFSDI...TENSATVSWTPP.....RSRVDSYRVSY...VP
#=GR TENA_CHICK/1317-1395  SS -.---.SEEEEES-...-SS-EEEEEE--.....SS--SEEEEEE...EE
FINC_BOVIN/875-955            KVPPP.RDLQFVEV...TDVKITIMWTPP.....ESPVTGYRVDV...IP
FINC_BOVIN/1511-1590          I.DKP.SQMQVTDV...QDNSISVRWLPS.....SSPVTGYRVTT...AP
TENA_CHICK/864-945            L.DAP.RNLKRVSQ...TDNSITLEWKNS.....HANIDNYRIKF...AP
TENA_CHICK/593-671            V.SPP.TELTVTNV...TDKTVNLEWKHE......NLVNEYLVTY...VP
FINC_BOVIN/1142-1225          PLSPP.TNLHLEAN..PDTGVLTVSWERST....TPDITGYRITT...TP
FINC_BOVIN/1693-1771          V.SPP.RRARVTDA...TETTITISWRTK.....TETITGFQVDA...IP
FINC_BOVIN/1236-1316          V.PPP.TDLRFTNV...GPDTMRVTWAPPS....SIELTNLLVRY...SP
FINC_BOVIN/1601-1680          I.PAP.TNLKFTQV...TPTSLTAQWTAP.....NVQLTGYRVRV...TP
TENA_CHICK/1494-1571          L.DAP.KDLSATEV...QSETAVITWRPP.....RAPVTDYLLTY...ES
TENA_CHICK/956-1033           L.DNP.KDLEVSDP...TETTLSLRWRRP.....VAKFDRYRLTY...VS
TENA_CHICK/682-767            L.PAP.EGLKFKSV...RETSVQVEWDPL.....SISFDGWELVFRNMQK
TENA_CHICK/774-853            L.DAP.SQIEAKDV...TDTTALITWSKP.....LAEIEGIELTY...GP
TENA_CHICK/1406-1483          L.DSP.SGLVVMNI...TDSEALATWQPA.....IAAVDNYIVSY...SS
FINC_BOVIN/1782-1861          I.DAP.SNLRFLAT...TPNSLLVSWQPP.....RARITGYIIKY...EK
PTPRB_HUMAN/1085-1162         P.AAV.TDLRITEN...STRHLSFRWTAS.....EGELSWYNIFL...YN
PTPRB_HUMAN/1173-1250         P.ASV.SHLRGSNR..NTTDSLWFNWSPA.....SGDFDFYELIL...YN
PTPRB_HUMAN/554-632           P.AQV.TDLHVANQ..GMTSSLFTNWTQA.....QGDVEFYQVLL...IH
PTPRB_HUMAN/643-725           P.SSV.SGVTVNNS..GRNDYLSVSWLVA.....PGDVDNYEVTL...SH
PTPRB_HUMAN/731-808           P.DKV.QGVSVSNS..ARSDYLRVSWVHA.....TGDFDHYEVTI...KN
PTPRB_HUMAN/995-1074          P.ASV.QGVIADNA..YSSYSLIVSWQKA.....AGVAERYDILL...LT
PTPRB_HUMAN/467-543           P.LAV.LQLRVKHA...NETSLSIMWQTP.....VAEWEKYIISL...AD
PTPRB_HUMAN/907-984           P.SAV.KNIHISPN..GATDSLTVNWTPG.....GGDVDSYTVSA...FR
PTPRB_HUMAN/112-192           P.PAR.FGVSKEKT...TSTGLHVWWTPS.....SGKVTSYEVQL...FD
PTPRB_HUMAN/1355-1434         P.DKI.QNLHCRPQ...NSTAIACSWIPP.....DSDFDGYSIECR...K
PTP10_DROME/583-661           P.NPP.RNMTIETV...RSNSVLVHWSPPE....SGEFTEYSIRYR...T
PTP10_DROME/312-394           P.LRP.LNVTFDRDF.ITSNSFRVLWEAPK...GISEFDKYQVSV...AT
PTP10_DROME/217-301           P.NTP.GKFIVWFR...NETTLLVLWQPPY...PAGIYTHYKVSI...EP
PTP10_DROME/123-205           P.DPP.SNLSVQVR...SGKNAIILWSPPT....QGSYTAFKIKV...LG
EPHA2_HUMAN/329-420           P.SAP.HYLTAVGM...GA.KVELRWTPPQD.SGGREDIVYSVTCEQCWP
EPHA1_HUMAN/333-431           P.SAP.RNLSFSA....SGTQLSLRWEPPAD.TGGRQDVRYSVRC...SQ
EPHB2_CHICK/326-422           P.SAP.QAV.ISSV...NETSLMLEWTPPRD.SGGREDLVYNIIC...KS
EPHA3_CHICK/325-421           P.SAP.RNV.ISNI...NETSVILDWSWPLD.TGGRKDVTFNIIC...KK
PTP10_DROME/864-944           P.EPI.TQLHATNI...TDTEISLRWDLP.....KGEYNDFDIAY...LT
PTPRB_HUMAN/1261-1344         P.SPP.SLMSFADI...ANTSLAITWKGPP...DWTDYNDFELQW...LP
TIE1_HUMAN/545-632            PLLQP.WLEGWHVE...GTDRLRVSWSLPLV.PGPLVGDGFLLRL...WD
7LESS_DROME/1799-1891         P.SPP.RNFSVRVL...SPRELEVSWLPPE..QLRSESVYYTLHW...QQ
PHB_ALCFA/344-418             G.SAP.TGLAVTAT...TSTSVSLSWNAV......ANASSYGV.YR....
APU_THETY/928-1009            A.PQPITDLKAVS....GNGKVDLSWSVV......DKAVSYNI.YR...S
CHIT_STRLI/142-219            P.SAP.GTPTASNI...TDTSVKLSWSAAT...DDKGVKNYDV.LR....
CHIA1_BACCI/465-542           P.SVP.GNARSTGV...TANSVTLAWNAST...DNVGVTGYNV.YN....
GUNB_CELFI/651-733            P.TTP.GTPVATGV...TTVGASLSWAAST..DAGSGVAGYEL.YR...V
CHIX_STROI/169-240            P.PAPPTGLRTGSV...TATSVALSWSPV......TGATGYAV.YR....
APU_THETY/1165-1248           P.TAP.V.LQQPGI...ESSRVTLNWSPSA...DDVAIFGYEIYK...SS
KALM_CHICK/177-269            P.LKPRKELKFIEL...QSGDLEVKWSSKF..NISIEPVIYVVQRR..WN
CNTN1_CHICK/799-884           PTEVP.TDVSVKVL...SSSEISVSWHHVT....EKSVEGYQIRY...WA
CNTN2_CHICK/807-896           PKVAP.FRVTAKAV...LSSEMDVSWEPVEQGDMTGVLLGYEIRY...WK
NRG_DROME/815-905             PLDAP.TNFTMRQI..TSSTSGYMAWTPVSEESVRGHFKGYKIQT...WT
L1CAM_HUMAN/812-907           P.QAI.PELEGIEI..LNSSAVLVKWRPVDLAQVKGHLRGYNVTY...WR
LAR_DROME/709-800             P.GDP.QDVKATPL...NSTSIHVSWKPPLEKDRNGIIRGYHIHA...QE
PTP99_DROME/171-259           P.SKP.QNLTILDV...SANSITMSWHPPK..NQNGAIAGYHVFH...IH
EPHA2_HUMAN/436-519           Q.TEP.PKVRLEGR...STTSLSVSWSIPP..PQQSRVWKYEVTYR...K
LAR_DROME/909-995             PGGPP.SNITIRFQ...TPDVLCVTWDPPTREHRNGIITRYDVQFH..KK
NRCAM_CHICK/928-1014          P.SPP.SFLKITNP...TLDSLTLEWGSPT..HPNGVLTSYILKF...QP
EPHB2_CHICK/437-521           P.SAV.SIMHQVSR...TVDSITLSWSQPD..QPNGVILDYELQY...YE
EPHA4_MOUSE/441-525           P.SSI.ALVQAKEV...TRYSVALAWLEPD..RPNGVILEYEVKY...YE
ITB4_HUMAN/1220-1310          P.SEP.GRLAFNVV...SSTVTQLSWAEPA..ETNGEITAYEVCY...GL
#=GR ITB4_HUMAN/1220-1310  SS -.---.---EEEEE...CTTEEEEE----S..--SS---EEEEEE...EE
ITB4_HUMAN/1641-1728          P.SAP.GPLVFTAL...SPDSLQLSWERPR..RPNGDIVGYLVTC...EM
ITB4_HUMAN/1528-1612          P.DTP.TRLVFSAL...GPTSLRVSWQEPR...CERPLQGYSVEY...QL
#=GC SS_cons                  -.---.CEEEEEEE...CTTEEEEEEE--S..--SS--SEEEEEEE..EE
#=GC seq_cons                 P.ssP.pslphpsh...sssslplsWpss.....suslssYplph....p

TIE1_HUMAN/644-729            AGGAG..........DPLWID...VDRP....EE.TSTIIRGL.NASTRY
NCAM1_BOVIN/509-597           MGEEVW.........HSKWYD...AKEA....SMEGIVTIVGL.KPETTY
LAR_DROME/417-503             TNSNQPE.......ASWNSQM...VDNS....E...LTTVSEL.TPHAIY
NGCA_CHICK/700-794            LEEPGGGGP..SGGFPWAEST...VDAP....P....VVVGGL.PPFSPF
MPSF_CHICK/499-585            VGSGS...........WQRVNAQVAVKS....P...RYAVFDL.AEGKPY
MPSF_CHICK/371-457            VGLEN...........WVQCN...DAPV....KI.CKYPVTGL.YEGRSY
MPSF_CHICK/600-684            VGSNQW........EPANHKP...INYN....R....FVVHGL.ETGEQY
NRCAM_CHICK/623-709           GLHEPG.........VWHYQT...EVPG....SH..TTVQLKL.SPYVNY
MYPC2_CHICK/631-717           KGSMRW.........MKLNFE...VFPD....T...TYESTKM.IEGVFY
MYLK_CHICK/1318-1403          SVDNK...........WTDLT...TCRS....T...SFNVQDL.QADREY
CNTN2_CHICK/602-692           LLSNKWK......QMRTNPVN...IEGN....AE..TAQVVNL.IPWMDY
MPSF_CHICK/699-785            ANHKN...........WHEVNSSVISRT....I....YTVEDL.TEDAFY
MPSF_CHICK/801-887            VDTED...........WITAN...EKPT....SH.RYFKVTDL.HQGHTY
MYPC2_CHICK/924-1006          TRTME...........WFTVL...EHSR....PT..RCTVSEL.VMGNEY
LAR_DROME/322-404             KNANQ...........AFSEI...SGII....TM..YYVVRAL.SPYTEY
FAS2_SCHAM/530-616            DSQGW...........EDALN...RTWP....VD.SPYILENL.KPQTRY
PTP69_DROME/332-425           SGEVPKV......IEEAIYQQ...NSRN....L...PYMFDKL.KTATDY
TENA_CHICK/1227-1306          KRKSD...........PLELI...VPGH....ER..THDITGL.KEGTEY
#=GR TENA_CHICK/1227-1306  SS T--EE...........EEEXX...E-TT....-S..EEEEES-.-TT-EE
TENA_CHICK/1136-1215          SNRLL..........EPMEFN...ISGN....SR..TAHISGL.SPSTDF
TENA_HUMAN/1529-1608          SGKLL..........DPQEFT...LSGT....QR..KLELRGL.ITGIGY
TENA_CHICK/1045-1124          SDNPE..........ETWNIT...VPGG....QH..SVNVTGL.KANTPY
TENA_HUMAN/1255-1335          ADQVE..........EAHNLT...VPGS....LR..SMEIPGL.RAGTPY
PTPRB_HUMAN/22-103            DTLGAA.........LCPTFR...IDNT....TY..GCNLQDL.QAGTIY
TIE2_HUMAN/639-724            QGKNE...........DQHVDV.KIKNA....TI.IQYQLKGL.EPETAY
LAR_DROME/515-598             TYANQ...........AHHKR...ISNS....E...AYTLDGL.YPDTLY
FINC_BOVIN/577-660            KNSPD..........RWKEAT...IPGH....LN..SYTIKGL.RPGVVY
TIE1_HUMAN/446-533            DSTMD...........WSTIV...VDPS....E...NVTLMNL.RPKTGY
PTPRK_MOUSE/290-376           T.SGS...........WTETH...AVNA....P...TYKLWHL.DPDTEY
TIE2_HUMAN/444-529            VNHYE..........AWQHIQ...VTNE....I....VTLNYL.EPRTEY
TIE2_HUMAN/543-626            VQKSD...........QQNIK...VPGN....LT..SVLLNNL.HPREQY
7LESS_DROVI/1917-1997         LREQ.............LQFN...VAGN....HT..QMRLAPL.QPKTRY
PTPRZ_HUMAN/312-401           LDGEDQ.........TKHEFL...TDGY....QD.LGAILNNL.LPNMSY
FAS2_SCHAM/642-735            VEKYDTEWR..LLPYPCQEHK...LEGQ....AT..TFQLESL.QPDTHY
NCAM1_BOVIN/610-691           LSSEW...........KPEIR...LPSG....SD..HVMLKSL.DWNAEY
ITB4_HUMAN/1127-1208          QGDSE..........SEAHLL...DSKV....P...SVELTNL.YPYCDY
#=GR ITB4_HUMAN/1127-1208  SS TTS-G..........GG-EEE...EESS....S...EEEE-S-.-TT-EE
UFO_HUMAN/327-411             QDTPE...........VLMDI...GLRQ....EV..TLELQGD.GSVSNL
KALM_CHICK/543-641            VTTESRQNSL.PNSIISQSQI...LPAD....HY..VLTVPNL.RPSMLY
PTP10_DROME/958-1044          INNLT...........DAGMQ...DFES....EE.AFGVIKNL.KPGETY
PTP69_DROME/236-321           AGTPTF........TYHKDFI...NGSH....T...SYILDHF.KPNTTY
NRG_DROME/917-1007            V.KESYVGE...RREYDPHIT...DPRV....T...RMKMAGL.KPNSKY
FINC_BOVIN/689-768            SEEGD..........EPQYLD...LPST....AT..SVNIPDL.LPGRKY
FINC_BOVIN/780-858            SVEGS...........STELN...LPET....AN..SVTLSDL.QPGVQY
IL7RA_HUMAN/129-221           KDENK...........WTHVN...LSST....KL..TLLQRKL.QPAAMY
PTP10_DROME/405-485           TFNGD...........TSTLT...TDRT....R....FTLESL.LPGRNY
FINC_BOVIN/1417-1499          TGGSS..........PVQEFT...VPGS....KS..TATISGL.KPGVDY
FINC_RAT/1266-1346            AGEGI..........PIFEDF...VDSS....VG..YYTVTGL.EPGIDY
FINC_BOVIN/1327-1406          ENMGG..........RPREDR...VPPS....RN..SITLTNL.NPGTEY
TENA_CHICK/1317-1395          ITGGT...........PNVVT...VDGS....KT..RTKLVKL.VPGVDY
#=GR TENA_CHICK/1317-1395  SS TT-B-...........-EEEE...EETT....-S..EEEE-S-.-SS-EE
FINC_BOVIN/875-955            VNLPGE.........HGQRLP...VSRN....T...FAEVTGL.SPGVTY
FINC_BOVIN/1511-1590          KNGPG..........PSKTKT...VGPD....QT..EMTIEGL.QPTVEY
TENA_CHICK/864-945            ISGGD...........HTELT...VPKGN.QATT..RATLTGL.RPGTEY
TENA_CHICK/593-671            TSSGG..........LDLQFT...VPGN....QT..SATIHEL.EPGVEY
FINC_BOVIN/1142-1225          TNGQQG.........YSLEEV...VHAD....QS..SCTFENL.SPGLEY
FINC_BOVIN/1693-1771          ANGQT...........PIQRT...IRPD....VR..SYTITGL.QPGTDY
FINC_BOVIN/1236-1316          VKNEE..........DVAELS...ISPS....DN..AVVLTNL.LPGTEY
FINC_BOVIN/1601-1680          KEKTG..........PMKEIN...LAPD....SS..SVVVSGL.MVATKY
TENA_CHICK/1494-1571          I.DGR...........VKEVI...LDPE....TT..SYTLTEL.SPSTQY
TENA_CHICK/956-1033           P.SGK...........KNEME...IPVD....ST..SFILRGL.DAGTEY
TENA_CHICK/682-767            KDDNG...........DITSS...LKRP....ET..SYMQPGL.APGQQY
TENA_CHICK/774-853            KDVPG..........DRTTID...LSED....EN..QYSIGNL.RPHTEY
TENA_CHICK/1406-1483          EDEP............EVTQM...VSGN....TV..EYDLNGL.RPATEY
FINC_BOVIN/1782-1861          PGSPPR.........EVVPRP...RPGV....T...EATITGL.EPGTEY
PTPRB_HUMAN/1085-1162         PDGNL..........QERAQV...DPLV....Q...SFSFQNL.LQGRMY
PTPRB_HUMAN/1173-1250         PNGTK..........KENWKD...KDLT....E....WRFQGL.VPGRKY
PTPRB_HUMAN/554-632           ENVV............IKNES...ISSE....TS..RYSFHSL.KSGSLY
PTPRB_HUMAN/643-725           DGKV............VQSLV...IAKS....VR..ECSFSSL.TPGRLY
PTPRB_HUMAN/731-808           KNNF............IQTKS...IPKS....EN..ECVFVQL.VPGRLY
PTPRB_HUMAN/995-1074          ENGIL...........LRNTS...EPAT....TK..QHKFEDL.TPGKKY
PTPRB_HUMAN/467-543           R.DLL...........LIHKS...LSKD....AK..EFTFTDL.VPGRKY
PTPRB_HUMAN/907-984           H.SQK...........VDSQT...IPKH....VF..EHTFHRL.EAGEQY
PTPRB_HUMAN/112-192           ENNQKIQ.......GVQIQES...TSWN....E....YTFFNL.TAGSKY
PTPRB_HUMAN/1355-1434         MDTQE..........VEFSRK...LEKE....KS..LLNIMML.VPHKRY
PTP10_DROME/583-661           DSEQQ...........WVRLP...SVRS....T...EADITDM.TKGEKY
PTP10_DROME/312-394           TRRQS...........TVPRS...NEPV....A...FFDFRDIAEPGKTF
PTP10_DROME/217-301           PDANDSV......LYVEKEGE...PPGP....A...QAAFKGL.VPGRAY
PTP10_DROME/123-205           LSEASS........SYNRTFQ...VNDN....TF..QHSVKEL.TPGATY
EPHA2_HUMAN/329-420           E.SGECGP.....CEASVRYS...EPPHG.LTRT..SVTVSDL.EPHMNY
EPHA1_HUMAN/333-431           CQGTAQDGGPCQPCGVGVHFSPGARGLT....TP..AVHVNGL.EPYANY
EPHB2_CHICK/326-422           CGSGRGAC....TRCGDNVQF...APRQLGLTEP..RIYISDL.LAHTQY
EPHA3_CHICK/325-421           CGGSSKIC....EPCSDNVRF...LPRQT.GLTN.TTVTVVDL.LAHTNY
PTP10_DROME/864-944           A.DNL...........LAQNM...TTRN....E....ITISDL.RPHRNY
PTPRB_HUMAN/1261-1344         RDALT..........VFNPYN...NRKS....E...GRIVYGL.RPGRSY
TIE1_HUMAN/545-632            GTRGQ...........ERREN...VSSP....QA.RTALLTGL.TPGTHY
7LESS_DROME/1799-1891         ELDGENVQD...RREWEAHER...RLET....AG..THRLTGI.KPGSGY
PHB_ALCFA/344-418             .NGS.............KVGS...ATAT....A....YTDSGL.IAGTTY
APU_THETY/928-1009            TVKGG...........LYEKI...ASNV....TQ.ITYTDTEV.TNGLKY
CHIT_STRLI/142-219            .DGA.............KVAT...VTGT....T....YTDNGL.TKGTAY
CHIA1_BACCI/465-542           .GAN.............LATS...VTGT....T....ATISGL.TAGTSY
GUNB_CELFI/651-733            QGTTQ...........TLVGT...TTAA....A....YILRDL.TPGTAY
CHIX_STROI/169-240            .DGV.............KVAT...ASGT....S....ATVTGL.TPDTAY
APU_THETY/1165-1248           SETGP..........FIKIAT...VSDS....VY..NYVDTDV.VNGNVY
KALM_CHICK/177-269            Q.GIHPSE.....DDATNWQT...VAQT....TD.ERVQLSDI.RASRWY
CNTN1_CHICK/799-884           AHDKEA.........AAQRVQ...VSNQ....EY..STKLENL.KPNTRY
CNTN2_CHICK/807-896           DGDKEE........AADRVRT...AGLV....T...SAHVTGL.NPNTKY
NRG_DROME/815-905             ENEGEE.........GLREIH...VKGD....TH..NALVTQF.KPDSKN
L1CAM_HUMAN/812-907           EGSQRKHSK...RHIHKDHVV...VPAN....TT..SVILSGL.RPYSSY
LAR_DROME/709-800             LRDEGKGF.....LNEPFKFD...VVDT....L...EFNVTGL.QPDTKY
PTP99_DROME/171-259           DNQTGVE.......IVKNSRN...SVET....LI..HFELQNL.RPYTDY
EPHA2_HUMAN/436-519           KGDS.............NSYN...VRRT....EG.FSVTLDDL.APDTTY
LAR_DROME/909-995             IDHGL...........GSERN...MTLR....K....AVFTNL.EENTEY
NRCAM_CHICK/928-1014          INNTHEL.......GPLVEIR...IPAN....ES..SLILKNL.NYSTRY
EPHB2_CHICK/437-521           KNLSE...........LNSTA...VKSP....TN..TVTVQNL.KAGTIY
EPHA4_MOUSE/441-525           KDQN............ERSYR...IVRT....AA.RNTDIKGL.NPLTSY
ITB4_HUMAN/1220-1310          VNDDNRP......IGPMKKVL...VDNP....KN.RMLLIENL.RESQPY
#=GR ITB4_HUMAN/1220-1310  SS B-TTS-B......-S--EEEE...E--T....T-.-EEEE---.-TT--E
ITB4_HUMAN/1641-1728          AQGGGP........ATAFRVD...GDSP....ES..RLTVPGL.SENVPY
ITB4_HUMAN/1528-1612          LNGGE...........LHRLN...IPNP....AQ.TSVVVEDL.LPNHSY
#=GC SS_cons                  TTTCC-B......-SGCEEEE...EETT....TS.-EEEEES-.-TT-EE
#=GC seq_cons                 tsssp...........hpphs...lsss....p...phslpsL.pPsspY

TIE1_HUMAN/644-729            LFRMR.ASI.QG....LGDWS
NCAM1_BOVIN/509-597           AVRLA.ALNGKG....LGEIS
LAR_DROME/417-503             TVRVQ.AYTSMG....AGPMS
NGCA_CHICK/700-794            QIRVQ.AVNGAG....KGPEA
MPSF_CHICK/499-585            VFRVL.SANKHG....ISDPS
MPSF_CHICK/371-457            IFRVR.AVNSAG....ISRPS
MPSF_CHICK/600-684            IFRVK.AVNAVG....FSENS
NRCAM_CHICK/623-709           SFRVI.AVNEIG....RSQPS
MYPC2_CHICK/631-717           EMRVF.AVNAIG....VSQPS
MYLK_CHICK/1318-1403          KFRVR.AANVYG....ISEPS
CNTN2_CHICK/602-692           EFRVL.ASNILG....VGEPS
MPSF_CHICK/699-785            EFKIA.AANVVG....IGHPS
MPSF_CHICK/801-887            VFKVR.AVNDAG....VGKSS
MYPC2_CHICK/924-1006          RFRVY.SENVC.......GTS
LAR_DROME/322-404             EFYVI.AVNNIG....RGPPS
FAS2_SCHAM/530-616            NFRFA.AQNEVG....FGPWS
PTP69_DROME/332-425           EFRVR.ACSDLTK..TCGPWS
TENA_CHICK/1227-1306          EIELY.GVSSG.......RRS
#=GR TENA_CHICK/1227-1306  SS EEEEE.EESSS.......-B-
TENA_CHICK/1136-1215          IVYLY.GISHG.......FRT
TENA_HUMAN/1529-1608          EVMVS.GFTQG.......HQT
TENA_CHICK/1045-1124          NVTLY.GVIRG.......YRT
TENA_HUMAN/1255-1335          TVTLH.GEVRG.......HST
PTPRB_HUMAN/22-103            NFKII.SLDEE........RT
TIE2_HUMAN/639-724            QVDIF.AENNIG....SSNPA
LAR_DROME/515-598             YIWLA.ARSQRG....EGATT
FINC_BOVIN/577-660            EGQLI.SVQHY......GQRE
TIE1_HUMAN/446-533            SVRVQLSRPGEGG...EGAWG
PTPRK_MOUSE/290-376           EIRVLLTRPGEGG...TGLPG
TIE2_HUMAN/444-529            ELCVQ.LVRRGE....GGEGH
TIE2_HUMAN/543-626            VVRAR..VNTKA....QGEWS
7LESS_DROVI/1917-1997         SCRLA.LAYAAT....PGAPI
PTPRZ_HUMAN/312-401           VLQIV.AICTNGL...YGKYS
FAS2_SCHAM/642-735            KVEVR.ATNAIG....NSVPG
NCAM1_BOVIN/610-691           EVYVV.AENQQ.......GKS
ITB4_HUMAN/1127-1208          EMKVC.AYGAQG....EGPYS
#=GR ITB4_HUMAN/1127-1208  SS EEEEE.EEETTE....E----
UFO_HUMAN/327-411             TVCVA.AYTAAG....DGPWS
KALM_CHICK/543-641            RLEVQ.VLTTGG....EGPAT
PTP10_DROME/958-1044          VFKIQ.AKTAIG....FGPER
PTP69_DROME/236-321           FLRIV.GKNSIG....NGQPT
NRG_DROME/917-1007            RISIT.ATTKMG....EGSEH
FINC_BOVIN/689-768            TVNVY.EISEE.......GEQ
FINC_BOVIN/780-858            NITIY.AVEEN.......QES
IL7RA_HUMAN/129-221           EIKVR.SIPDHYFKGFWSEWS
PTP10_DROME/405-485           SLSVQ.AVSKK.......MES
FINC_BOVIN/1417-1499          TITVY.AVTGRG....DSPAS
FINC_RAT/1266-1346            DISVI.TLING.......GES
FINC_BOVIN/1327-1406          VVSIV.ALNSK.......EES
TENA_CHICK/1317-1395          NVNII.SVKGF.......EES
#=GR TENA_CHICK/1317-1395  SS EEEEE.EEETT.......EE-
FINC_BOVIN/875-955            HFKVF.AVNQG.......RES
FINC_BOVIN/1511-1590          VVSVY.AQNQN.......GES
TENA_CHICK/864-945            GIGVT.AVRQD.......RES
TENA_CHICK/593-671            FIRVF.AILKN.......KKS
FINC_BOVIN/1142-1225          NVSVY.TVKDD.......KES
FINC_BOVIN/1693-1771          KIHLY.TLNDN.......ARS
FINC_BOVIN/1236-1316          LVSVS.SVYEQ.......HES
FINC_BOVIN/1601-1680          EVSVY.ALKDT.......LTS
TENA_CHICK/1494-1571          TVKLQ.ALSRS.......MRS
TENA_CHICK/956-1033           TISLV.AEKGR.......HKS
TENA_CHICK/682-767            NVSLH.IVKNNTR...GPGLS
TENA_CHICK/774-853            EVTLI.SRRGD.......MES
TENA_CHICK/1406-1483          TLRVH.AVKDA.......QKS
FINC_BOVIN/1782-1861          TIQVI.ALKNN.......QKS
PTPRB_HUMAN/1085-1162         KMVIV.THSGE........LS
PTPRB_HUMAN/1173-1250         VLWVV.THSGD........LS
PTPRB_HUMAN/554-632           SVVVT.TVSGG.......ISS
PTPRB_HUMAN/643-725           TVTIT.TRSGKYE...NHSFS
PTPRB_HUMAN/731-808           SVTVT.TKSGQ........YE
PTPRB_HUMAN/995-1074          KIQIL.TVSGG.......LFS
PTPRB_HUMAN/467-543           MATVT.SISGD........LK
PTPRB_HUMAN/907-984           QIMIA.SVSGS........LK
PTPRB_HUMAN/112-192           NIAIT.AVSGG.......KRS
PTPRB_HUMAN/1355-1434         LVSIK.VQSAG.......MTS
PTP10_DROME/583-661           TIQVN.TVSFG.......VES
PTP10_DROME/312-394           NVIVK.TVSGK.......VTS
PTP10_DROME/217-301           NISVQ.TMSED.......EIS
PTP10_DROME/123-205           QVQAY.TIYDG.......KES
EPHA2_HUMAN/329-420           TFTVE.ARNGV........SG
EPHA1_HUMAN/333-431           TFNVE.AQNGVS....GLGSS
EPHB2_CHICK/326-422           TFEIQ.AVNGVTD...QSPFS
EPHA3_CHICK/325-421           TFEID.AVNGVSD...LSTLS
PTP10_DROME/864-944           TFTVV.VRSGTES..SVLRSS
PTPRB_HUMAN/1261-1344         QFNVK.TVSGDS....WKTYS
TIE1_HUMAN/545-632            QLDVQ.LYHCTL....LGPAS
7LESS_DROME/1799-1891         SLWVQ.AHATPT....KSNSS
PHB_ALCFA/344-418             SYTVT.AVDPTAG...ESQPS
APU_THETY/928-1009            VYAVT.AVDNDGN...ESALS
CHIT_STRLI/142-219            SYSVK.ARDTADQ...TGPAS
CHIA1_BACCI/465-542           TFTIK.AKDAAGN...LSAAS
GUNB_CELFI/651-733            SYVVK.AKDVAGN...VSAAS
CHIX_STROI/169-240            AFQVA.AVNGA.......GES
APU_THETY/1165-1248           YYKVV.AVDTSY....NRTAS
KALM_CHICK/177-269            QFRVA.AVNVHG....TRGFT
CNTN1_CHICK/799-884           HIDVS.AFNSAG....YGPPS
CNTN2_CHICK/807-896           HVSVR.AYNRAG....AGPPS
NRG_DROME/815-905             YARIL.AYNGRF....NGPPS
L1CAM_HUMAN/812-907           HLEVQ.AFNGRG....SGPAS
LAR_DROME/709-800             SIQVA.ALTRKG....DGDRS
PTP99_DROME/171-259           RVIVK.AFTTKN....EGEPS
EPHA2_HUMAN/436-519           LVQVQ.ALTQEG....QGAGS
LAR_DROME/909-995             IFRVR.AYTKQG....AGPFS
NRCAM_CHICK/928-1014          KFYFN.AQTSV......GSGS
EPHB2_CHICK/437-521           VFQVR.ARTVAG....YGRYS
EPHA4_MOUSE/441-525           VFHVR.ARTAAG....YGDFS
ITB4_HUMAN/1220-1310          RYTVK.ARNGAG....WGPER
#=GR ITB4_HUMAN/1220-1310  SS EEEEE.EEETTE....E--BE
ITB4_HUMAN/1641-1728          KFKVQ.ARTTEG....FGPER
ITB4_HUMAN/1528-1612          VFRVR.AQSQEG....WGRER
#=GC SS_cons                  EEEEE.EEETTE....E-EBE
#=GC seq_cons                 phpVt.Ahsst.......t.S
//
